Remyelination and Nerve Repair
Electrical insulation of nerve fibers by a multilamellar myelin sheath is a prerequisite of fast impulse propagation. Myelin is produced by oligodendrocytes and Schwann cells in the central (CNS) and peripheral nervous system (PNS). The aquired or inherited inability to maintain myelination is the cause for frequent neurological disorders including multiple sclerosis in the CNS and demyelinating neuropathies in the PNS - debilitating diseases without known cure.
With the help of transgenic techniques in mice, a battery of state of the art behavioral and electrophysiological methods, high resolution microscopy and next generation sequencing approaches, we aim to unravel pathological mechanisms that help to identify therapeutic targets for this life-burdening diseases.